CANNABIDIOL A THERAPEUTIC POTENTIAL IN THE TREATMENT OF EPILEPSY AND ITS MECHANISMS OF ACTION: A SYSTEMATIC REVIEW

Authors

  • Thamires Karoline de Lima Universidade federal de Pernambuco
  • Sara Maria Xavier da Cruz Universidade Federal de Pernambuco
  • Ingrid Thayanne Souza Alves da Silva Faculdade Pernambucana de Saúde
  • Karen Eduarda Carvalho da Silva Universidade Federal de Pernambuco

DOI:

https://doi.org/10.31692/2764-3433.v5i1.298

Keywords:

Cannabidiol, Epilepsy, CB1 receptors, Endocannabinoid system, Seizures

Abstract

Introduction:  Cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa, is studied for its therapeutic potential, particularly in neurological disorders like epilepsy. Objectives:Analyze the mechanisms of CBD action in brain cells of individuals with epilepsy, focusing on the involved signaling pathways. Methodology: A systematic review was conducted using “Cannabidiol” and “Epilepsy” in PubMed, Scopus, and SciELO (2019–2024), selecting ten articles. Results: CBD may reduce seizures, especially in refractory  cases, by interacting with the endocannabinoid system and modulating CB1 and CB2 receptors. Further research is needed to clarify its mechanisms. Conclusion: CBD shows promising therapeutic effects in epilepsy, but further research is essential to optimize its clinical use. 

 

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Published

2025-06-30

Issue

Vol. 5 No. 1 (2025): International Journal of Health Sciences - PDVS

Section

Artigos

License

Copyright (c) 2025 International Journal of Health Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

CANNABIDIOL A THERAPEUTIC POTENTIAL IN THE TREATMENT OF EPILEPSY AND ITS MECHANISMS OF ACTION: A SYSTEMATIC REVIEW. (2025). International Journal of Health Sciences, 5(1), 65-76. https://doi.org/10.31692/2764-3433.v5i1.298

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